Bivalent Junin & Machupo experimental vaccine based on alphavirus RNA replicon vector
نویسندگان
چکیده
منابع مشابه
Alphavirus vector-based replicon particles expressing multivalent cross-protective Lassa virus glycoproteins
Lassa virus (LASV) is the most prevalent rodent-borne arenavirus circulated in West Africa. With population at risk from Senegal to Nigeria, LASV causes Lassa fever and is responsible for thousands of deaths annually. High genetic diversity of LASV is one of the challenges for vaccine R&D. We developed multivalent virus-like particle vectors (VLPVs) derived from the human Venezuelan equine ence...
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Arenaviruses are rodent-borne emerging human pathogens. Diseases caused by these viruses, e.g., Lassa fever (LF) in West Africa and South American hemorrhagic fevers (HFs), are serious public health problems in endemic areas. We have employed replication-competent and replication-deficient strategies to design vaccine candidates potentially targeting different groups "at risk". Our leader LF va...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2020
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2020.02.053